Piperidine derivatives; C-alkylation of l-benzoyl-3-carbethoxy-4-piperidone; synthesis of ethyl 3-ethyl-4-piperidylacetate (d1-ethyl cincholoiponate).

@article{Stork1946PiperidineDC,
  title={Piperidine derivatives; C-alkylation of l-benzoyl-3-carbethoxy-4-piperidone; synthesis of ethyl 3-ethyl-4-piperidylacetate (d1-ethyl cincholoiponate).},
  author={Gilbert Stork and Samuel M. McElvain},
  journal={Journal of the American Chemical Society},
  year={1946},
  volume={68},
  pages={
          1053-7
        }
}
  • G. Stork, S. McElvain
  • Published 1 June 1946
  • Chemistry, Medicine
  • Journal of the American Chemical Society
had resolidified. Benzoic acid appeared as a sublimate on the cooler portions of the test-tube and a faint odor of benzoyl chloride was noticeable. After cooling, chloroform was added to the remaining solid to dissolve any benzoic acid and unchanged IX; the white solid remaining undissolved by this solvent was guvacine hydrochloride and it was substantially pure as obtained, m. p. 304405' d. with previous darkening (previously reported melting points: 309-314' d.: 312',11 316' d.la)). The… Expand
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