Piperidine, pyridine alkaloid inhibition of fetal movement in a day 40 pregnant goat model.

@article{Green2013PiperidinePA,
  title={Piperidine, pyridine alkaloid inhibition of fetal movement in a day 40 pregnant goat model.},
  author={Benedict T. Green and Stephen T Lee and Kevin D Welch and James A. Pfister and Kip E. Panter},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={58},
  pages={8-13}
}
Inhibition of fetal movement is one mechanism behind the development of multiple congenital contracture-type defects in developing fetuses of humans and animals. We tested the alkaloids anabasine, lobeline, and myosmine for agonist actions, and sensitivity to alpha conotoxins EI and GI blockade at fetal muscle-type nicotinic acetylcholine receptors (nAChR) expressed by TE-671 cells. We also determined if the alkaloids decreased fetal movement in an IV dosed, day 40 pregnant goat model. In TE… CONTINUE READING
5 Citations
58 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 58 references

The role of the a7 subunit of the nicotinic acetylcholine receptor in the acute toxicosis of methyllycaconitine in mice

  • Welch
  • J. Appl. Toxicol.. http:// dx.doi.org/10.1002/jat…
  • 2013

Similar Papers

Loading similar papers…