Piperacillin-tazobactam plus amikacin versus ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer.

@article{Cometta1995PiperacillintazobactamPA,
  title={Piperacillin-tazobactam plus amikacin versus ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer.},
  author={Alain Cometta and Stephen H. Zinner and Robrecht de Bock and Thierry F Calandra and Harold Gaya and Jean A. Klastersky and J Langenaeken and Marianne Paesmans and Claudio Viscoli and Michel Pierre Glauser},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 2},
  pages={445-52}
}
Gram-positive bacteria have become the predominant infecting organisms in granulocytopenic cancer patients. Empiric antibiotic regimens used in febrile neutropenic patients often include an extended-spectrum cephalosporin, but the response to therapy in gram-positive coccal bacteremia has been unsatisfactory. Thus, new antibiotics with better activity against gram-positive bacteria should be tested. The objective of this prospective randomized controlled study was to evaluate and compare the… CONTINUE READING
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