Piperacillin/Tazobactam vs Imipenem/Cilastatin in the Treatment of Nosocomial Pneumonia—a Double Blind Prospective Multicentre Study

@article{Schmitt2006PiperacillinTazobactamVI,
  title={Piperacillin/Tazobactam vs Imipenem/Cilastatin in the Treatment of Nosocomial Pneumonia—a Double Blind Prospective Multicentre Study},
  author={Dierck V Schmitt and Eva Leitner and Tobias Welte and Hartmut M Lode},
  journal={Infection},
  year={2006},
  volume={34},
  pages={127-134}
}
Piperacillin/tazobactam (P/T) with its broad spectrum of antibacterial activity is used widely for the treatment of moderate to severe polymicrobial nosocomial infections. The efficacy and safety of P/T was compared with imipenem/cilastatin (I/C) in patients with established nosocomial pneumonia. This multicentre study took place from January 1999 to December 2001. Due to difficulties in recruiting sufficient patients it was terminated prematurely. In all, 221 patients were randomly assigned to… CONTINUE READING

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