Piperacillin/Tazobactam

@article{Bryson2012PiperacillinTazobactam,
  title={Piperacillin/Tazobactam},
  author={Harriet M. Bryson and Rex N. Brogden},
  journal={Drugs},
  year={2012},
  volume={47},
  pages={506-535}
}
AbstractSynopsisCombining tazobactam, a β-lactamase inhibitor, with the ureidopenicillin, piperacillin, successfully restores the activity of piperacillin against β-lactamase-producing bacteria. Tazobactam has inhibitory activity, and therefore protects piperacillin against Richmond and Sykes types II, III, IV and V β-lactamases, staphylococcal penicillinase and extended-spectrum β-lactamases. However, tazobactam has only species-specific activity against class I chromosomally-mediated enzymes… 

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

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Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Ceftolozane in an In Vitro Infection Model

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Results indicate that p Piperacillin is rapidly absorbed and reaches high initial concentrations; however, it is also rapidly eliminated in the Hispaniolan Amazon parrot, and tazobactam has similar pharmacokinetics as piperacillin.

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References

SHOWING 1-10 OF 80 REFERENCES

Imipenem/Cilastatin

TLDR
Imipenem/cilastatin is effective as initial monotherapy of a variety of infections, including infections in neutropenic patients, with a clear role in empirical treatment of mixed infection.

Comparative in vitro activities of amoxicillin-clavulanate, ampicillin-sulbactam and piperacillin-tazobactam against strains of escherichia coli and proteus mirabilis harbouring known β-lactamases

TLDR
Strains ofEscherichia coli and Proteus mirabilis harboring known β-lactamases showed significant differences in susceptibilities to the various combinations, suggesting that, at least in strains resistant to one combination, several β-Laktamase-Inhibitor-Kombination combinations should be tested in the laboratory.

Comparative in vitro activities of piperacillin-tazobactam and ticarcillin-clavulanate

TLDR
For relatively susceptible strains of members of the family Enterobacteriaceae, neither combination was predictably more active than the other, but relatively resistant strains were generally more susceptible to piperacillin-tazobactam.

Comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam.

TLDR
Tazobactam and clavulanic acid were superior to sulbactam in enhancing the therapeutic efficacy of piperacillin in mice infected with beta-lactamase-positive E. coli, K. pneumoniae, Proteus mirabilis, and Staphylococcus aureus.

Effect of piperacillin/tazobactam therapy on intestinal microflora.

TLDR
The effect of piperacillin/tazobactam treatment upon the intestinal microflora was studied in 20 patients with intraabdominal infections and there was a minor decrease in the number of bifidobacteria, eubacteria, lactobacilli, clostridia and veillonella but the numbers of anaerobic Gram-positive cocci and bacteroides were not influenced by the treatment.

Studies to optimize the in vitro testing of piperacillin combined with tazobactam (YTR 830).

  • R. JonesA. Barry
  • Biology, Medicine
    Diagnostic microbiology and infectious disease
  • 1989

Susceptibility of beta-lactamase-producing enterococci to piperacillin with tazobactam.

Interactions of tazobactam and clavulanate with inducibly- and constitutively-expressed Class I beta-lactamases.

TLDR
The piperacillin + tazobactam combination, unlike ticarcillin + clavulanate, showed some degree of synergy against most derepressed strains of these species, but it is in the last two species that these enzymes pose the greatest resistance threat.

Susceptibility of anaerobes in phase 3 clinical studies of piperacillin/tazobactam.

TLDR
In this study, the in vitro susceptibility of anaerobic pathogens to piperacillin/tazobactam and other antimicrobial agents used in the treatment ofAnaerobic infections was determined based on results for 532 isolates obtained from patients enrolled in clinical trials for evaluation of the safety and efficacy of the p Piperacillin-tazOBactam combination.

Evaluation of piperacillin-tazobactam in experimental meningitis caused by a beta-lactamase-producing strain of K1-positive Escherichia coli

TLDR
Combination treatment of piperacillin combined with tazobactam in experimental meningitis resulted in significantly better bactericidal activity in the cerebrospinal fluid.
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