Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein.

@article{Juli2011PipecolicAD,
  title={Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein.},
  author={Christina Juli and Martin Sippel and Jens J{\"a}ger and Alexandra Thiele and Matthias Weiwad and Kristian Schweimer and Paul R{\"o}sch and Michael Steinert and Christoph A. Sotriffer and Ulrike Holzgrabe},
  journal={Journal of medicinal chemistry},
  year={2011},
  volume={54 1},
  pages={277-83}
}
The macrophage infectivity potentiator (MIP) protein is a major virulence factor of Legionella pneumophila, the causative agent of Legionnaires' disease. MIP belongs to the FK506-binding proteins (FKBP) and is necessary for optimal intracellular survival and lung tissue dissemination of L. pneumophila. We aimed to identify new small-molecule inhibitors of MIP by starting from known FKBP12 ligands. Computational analysis, synthesis, and biological testing of pipecolic acid derivatives revealed a… CONTINUE READING

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