Pioneer neurons in the mouse trigeminal sensory system.

  title={Pioneer neurons in the mouse trigeminal sensory system.},
  author={Didier Y. R. Stainier and Walter Gilbert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 3},
Pioneer neurons establish preliminary nerve pathways that are followed by later-growing axons. The existence of pioneers and their importance is well documented in invertebrate systems. In mammals, early neuronal development has generally been difficult to study because of the size and complexity of the embryos, and the lack of adequate markers. Here we look at the time of earliest axonal outgrowth in the mouse embryo by using specific monoclonal antibodies to stain wholemount preparations… CONTINUE READING