Pioneer growth cone steering decisions mediated by single filopodial contacts in situ.

@article{OConnor1990PioneerGC,
  title={Pioneer growth cone steering decisions mediated by single filopodial contacts in situ.},
  author={Timothy P. O'Connor and Janet S. Duerr and David Bentley},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1990},
  volume={10 12},
  pages={3935-46}
}
In grasshopper embryo limb buds, the sibling Ti1 pioneers are the first neurons to initiate axonogenesis. The pioneer growth cones migrate from the limb tip to the CNS along a in direction comprising discrete steering events. Filopodial exploration of the cellular terrain in the vicinity of the advancing growth cone appears to be important for steering. Some information is available on the identity of cells and cell types, on cell-surface characteristics, and on the involvement of basal lamina… CONTINUE READING