Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.

@article{Chang2010PioglitazoneSI,
  title={Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.},
  author={Kiyuk Chang and Sanjeev A. Francis and Elena Aikawa and Jose-Luiz Figueiredo and Rainer H Kohler and Jason R. McCarthy and Ralph Weissleder and Jorge Plutzky and Farouc A. Jaffer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 10},
  pages={1933-9}
}
OBJECTIVE To investigate the effects of pioglitazone (PIO), a peroxisome proliferator-activated receptor γ agonist, on plaque matrix metalloproteinase (MMP) and macrophage (Mac) responses in vivo in a molecular imaging study. METHODS AND RESULTS In vitro, PIO suppressed MMP-9 protein expression in murine peritoneal Macs (P<0.05). To assess PIO's effects on plaque inflammation, nondiabetic apolipoprotein E(-/-) mice receiving a high-cholesterol diet (HCD) were administered an MMP-activatable… CONTINUE READING
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To investigate the effects of pioglitazone ( PIO ) , a peroxisome proliferator - activated receptor γ agonist , on plaque matrix metalloproteinase ( MMP ) and macrophage ( Mac ) responses in vivo in a molecular imaging study .
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