Pioglitazone reduces secondary brain damage after experimental brain trauma by PPAR-γ-independent mechanisms.

@article{Thal2011PioglitazoneRS,
  title={Pioglitazone reduces secondary brain damage after experimental brain trauma by PPAR-γ-independent mechanisms.},
  author={Serge C Thal and Marius Heinemann and Clara Luh and Dana Pieter and Christian Werner and Kristin Engelhard},
  journal={Journal of neurotrauma},
  year={2011},
  volume={28 6},
  pages={983-93}
}
Inflammatory and ischemic processes contribute to the development of secondary brain damage after mechanical brain injury. Recent data suggest that thiazolidinediones (TZDs), a class of drugs approved for the treatment of non-insulin-dependent diabetes mellitus, effectively reduces inflammation and brain lesion by stimulation of the peroxisome proliferator-activated receptor-γ (PPAR-γ). The present study investigates the influence of the TZD pioglitazone and rosiglitazone on inflammation and… CONTINUE READING

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in hamsters by pioglitazone , a ligand of peroxisome proliferator - activated receptor gamma

  • S. C. Thal, S. Wyschkon, D. Pieter, K. Engelhard, C. Werner
  • 2008
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