Pioglitazone protects against thrombosis in a mouse model of obesity and insulin resistance.

@article{Bodary2005PioglitazonePA,
  title={Pioglitazone protects against thrombosis in a mouse model of obesity and insulin resistance.},
  author={Peter F. Bodary and Fernando B. Vargas and Serina A King and Kathryn L Jongeward and Kevin J Wickenheiser and Daniel T. Eitzman},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2005},
  volume={3 10},
  pages={2149-53}
}
BACKGROUND As arterial thrombosis accounts for the vast majority of cardiovascular complications in obese, insulin resistant patients, we hypothesized that improving insulin sensitivity may be effective in reducing the thrombotic response following vascular injury. OBJECTIVES We investigated the effect of the thiazolidinedione drug, pioglitazone, on the thrombotic response to injury in obese, insulin resistant mice. METHODS Insulin-resistant, obesity-prone mice (KK strain) were treated with… CONTINUE READING