Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage.

@article{Sumita2004PioglitazoneIP,
  title={Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage.},
  author={Chinuyo Sumita and Makiko Maeda and Yasushi Fujio and Jooyeon Kim and Junko Fujitsu and Soji Kasayama and Isamu Yamamoto and Junichi Azuma},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1673 3},
  pages={115-21}
}
Platelet activating factor (PAF) is a key molecule for inflammation. To examine a role of peroxisome proliferator-activated receptor gamma (PPARgamma) in inflammatory reactions of atherosclerosis, we investigated the effects of 15-deoxy-(Delta12,14)-Prostaglandin J2 (15d-PGJ2) and pioglitazone, PPARgamma ligands, on plasma PAF-acetylhydrolase (PAF-AH) expression in THP-1 macrophages. PAF-AH mRNA and protein were up-regulated by the PPARgamma ligands. Prostaglandin F2alpha (PGF2alpha), a… CONTINUE READING