Pioglitazone induces apoptosis in human vascular smooth muscle cells from diabetic patients involving the transforming growth factor-beta/activin receptor-like kinase-4/5/7/Smad2 signaling pathway.

@article{Ruiz2007PioglitazoneIA,
  title={Pioglitazone induces apoptosis in human vascular smooth muscle cells from diabetic patients involving the transforming growth factor-beta/activin receptor-like kinase-4/5/7/Smad2 signaling pathway.},
  author={E. del V. Ruiz and S Castellanos Redondo and Antonio Gordillo-Moscoso and Teresa Tejerina},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={321 2},
  pages={431-8}
}
Alterations in vascular wall remodeling are a typical complication in type 2 diabetes mellitus due to an imbalance between cell proliferation and apoptosis. In this context, we have previously shown that vascular smooth muscle cells (VSMC) from diabetic patients were resistant to induced apoptosis. Thiazolidinediones, such as pioglitazone, seem to exert… CONTINUE READING