Pioglitazone increases apolipoprotein A-I production by directly enhancing PPRE-dependent transcription in HepG2 cells.

@article{Zhang2010PioglitazoneIA,
  title={Pioglitazone increases apolipoprotein A-I production by directly enhancing PPRE-dependent transcription in HepG2 cells.},
  author={Lin-hua Zhang and Vaijinath S. Kamanna and Shobha H Ganji and Xi-Ming Xiong and Moti L. Kashyap},
  journal={Journal of lipid research},
  year={2010},
  volume={51 8},
  pages={2211-22}
}
Pioglitazone, a hypoglycemic agent, has been shown to increase plasma HDL cholesterol, but the mechanism is incompletely understood. We further investigated effects of pioglitazone on transcriptional regulation of apolipoprotein (apo)A-I gene and functional properties of pioglitazone-induced apoA-I-containing particles. Pioglitazone dose-dependently stimulated apoA-I promoter activities in HepG2 cells. A peroxisome proliferator-activated receptor (PPAR)-response element located in site A (-214… CONTINUE READING

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