Pioglitazone Improves Fat Distribution, the Adipokine Profile and Hepatic Insulin Sensitivity in Non-Diabetic End-Stage Renal Disease Subjects on Maintenance Dialysis: A Randomized Cross-Over Pilot Study

@inproceedings{Zanchi2014PioglitazoneIF,
  title={Pioglitazone Improves Fat Distribution, the Adipokine Profile and Hepatic Insulin Sensitivity in Non-Diabetic End-Stage Renal Disease Subjects on Maintenance Dialysis: A Randomized Cross-Over Pilot Study},
  author={Anne Zanchi and Luc Tappy and Kim-Anne L{\^e} and Murielle Bortolotti and Nicolas Theumann and Georges Habib Halabi and Thierry Gauthier and Claudine M Mathieu and Sylvie TremblayS. Tremblay and Pauline Coti Bertrand and Michel Antoine Burnier and Daniel Teta and Stephen L Atkin},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Fat redistribution, increased inflammation and insulin resistance are prevalent in non-diabetic subjects treated with maintenance dialysis. The aim of this study was to test whether pioglitazone, a powerful insulin sensitizer, alters body fat distribution and adipokine secretion in these subjects and whether it is associated with improved insulin sensitivity. TRIAL DESIGN This was a double blind cross-over study with 16 weeks of pioglitazone 45 mg vs placebo involving 12 subjects… CONTINUE READING

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