Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm.

@article{Charolidi2015PioglitazoneIA,
  title={Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm.},
  author={Nicoletta Charolidi and Grisha Pirianov and Evelyn Torsney and Stuart Pearce and Ken Laing and Axel Nohturfft and Gillian W. Cockerill},
  journal={Journal of vascular research},
  year={2015},
  volume={52 2},
  pages={81-93}
}
Peroxisome proliferator-activated receptor x03B3; agonists have been shown to inhibit angiotensin II (AngII)-induced experimental abdominal aortic aneurysms. Macrophage infiltration to the vascular wall is an early event in this pathology, and therefore we explored the effects of the peroxisome proliferator-activated receptor x03B3; agonist pioglitazone on AngII-treated macrophages. Using microarray-based expression profiling of phorbol ester-stimulated THP-1 cells, we found that a number of… CONTINUE READING