Pioglitazone‐induced myofibroblast cell death: implications for cutaneous scarring

@article{OLeary2003PioglitazoneinducedMC,
  title={Pioglitazone‐induced myofibroblast cell death: implications for cutaneous scarring},
  author={Ronan O'Leary and Sreenivasan Ponnambalam and Edward J. Wood},
  journal={British Journal of Dermatology},
  year={2003},
  volume={149}
}
Wound healing potential of scaffolds prepared from porcine jejunum and urinary bladder by a non-detergent/enzymatic method
TLDR
The results suggested that JDS and UDS prepared by non-detergent/enzymatic method have potential clinical applications and induced higher cell proliferation and greater angiogenesis than UDS probably indicating better healing by the former.
Rosiglitazone modulates the behaviors of diabetic host‐derived fibroblasts in a carboxymethyllysine‐modified collagen model
  • Huijuan Liao, I. Pastar, Weiliam Chen
  • Biology
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2012
TLDR
Rosiglitazone induced fibroblast migration, α‐smooth muscle actin production, and transformation into myofibroblasts in the presence of advanced glycation end products, and its potential as a topical treatment of diabetic chronic wounds is identified.
Rosiglitazone increases matrix production and quenches inflammation: studies in human cells
TLDR
The effect of therapeutic doses of rosiglitazone on proliferative and inflammatory pathways in fibroblasts (HF) from five controls and five T2D patients, and in aortic smooth muscle cells (hSMC) is tested.
Thiazolidinediones in dermatology
  • A. Boyd
  • Medicine, Biology
    International journal of dermatology
  • 2007
TLDR
Clinicians should become familiar with glitazones as they are experiencing a burgeoning use among patients with non‐insulin‐dependent diabetes mellitus and have demonstrated clinical efficacy in treating certain skin conditions.
Author index
  • Medicine
  • 2003
TLDR
The IgA and IgG response to the epidermal antigens demonstrates that intermolecular epitope spreading is associated with IgA rather than IgG antibodies, and is more common in adults than in children.

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The results indicate that the number of myofibroblastic and vascular cells undergoing apoptosis increases as the wound closes and support the assumption that this is the mechanism of granulation tissue evolution into a scar.
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