Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells

@article{Jin2014PinocembrinA6,
  title={Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells},
  author={Xiaohua Jin and Qian Liu and Lili Jia and Mingjie Li and Xuan Wang},
  journal={Cellular and Molecular Neurobiology},
  year={2014},
  volume={35},
  pages={323-333}
}
Pinocembrin (PB), the most abundant flavonoid in propolis, has been known to display antioxidant activity. However, the mechanism as how PB can induce antioxidant activity remains elusive. The purpose of the present study was to investigate the potential neuroprotective role of PB and to delineate its mechanism of action against the Parkinson’s disease-related neurotoxin 6-hydroxydopamine(6-OHDA)-induced cell death in neuroblastoma SH-SY5Y cells. Results indicate that pretreatment with PB for 4… CONTINUE READING
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Heme oxygenase - 1 protects human melanocytes from H 2 O 2 - induced oxidative stress via the Nrf 2 - ARE pathway

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