Pink-eyed dilution protein controls the processing of tyrosinase.

  title={Pink-eyed dilution protein controls the processing of tyrosinase.},
  author={Kun Chen and Prashiela Manga and Seth J Orlow},
  journal={Molecular biology of the cell},
  volume={13 6},
The processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis, was investigated in melan-p1 melanocytes, which are null at the p locus. Endoglycosidase H digestion showed that a significant fraction of tyrosinase was retained in the endoplasmic reticulum. This retention could be rescued either by transfection of melan-p1 cells with an epitope-tagged wild-type p transcript or by treatment with either bafilomycin A1 or ammonium chloride. We found that the endoplasmic… CONTINUE READING


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