Pinealectomy increases and exogenous melatonin decreases leptin production in rat anterior pituitary cells: an immunohistochemical study.

@article{Ku2004PinealectomyIA,
  title={Pinealectomy increases and exogenous melatonin decreases leptin production in rat anterior pituitary cells: an immunohistochemical study.},
  author={Ilter Kuş and Mustafa Sarsilmaz and Neriman Çolakoğlu and A Kukne and Oğuz Aslan Ozen and Bayram Yilmaz and Haluk Kelestimur},
  journal={Physiological research},
  year={2004},
  volume={53 4},
  pages={
          403-8
        }
}
Melatonin, the main hormone of the pineal gland, informs the body about the environmental light and darkness regimen, which in turn contributes to the photoperiodic adaptation of several physiological functions. Leptin, the hormone secreted mainly by adipocytes and some other tissues including the pituitary, informs the brain about the mass of adipose tissue, which plays an important role in energy homeostasis. Melatonin has been shown to decrease circulating leptin levels. It is currently not… CONTINUE READING