Pineal melatonin inhibition of tumor promotion in theN-nitroso-N-methylurea model of mammary carcinogenesis: potential involvement of antiestrogenic mechanisms in vivo

@article{Blask1991PinealMI,
  title={Pineal melatonin inhibition of tumor promotion in theN-nitroso-N-methylurea model of mammary carcinogenesis: potential involvement of antiestrogenic mechanisms in vivo},
  author={David E. Blask and Diane B. Pelletier and Steven Marc Hill and Athena Lemus-Wilson and David S. Grosso and Sean T. Wilson and Mark E. Wise},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1991},
  volume={117},
  pages={526-532}
}
TheN-methyl-N-nitrosurea (NMU) model of hormone-responsive rat mammary carcinogenesis was used to address the hypothesis that melatonin (Mel), the principle hormone of the pineal gland, inhibits tumorigenesis by acting as an anti-promoting rather than an anti-initiating agent. Daily late-afternoon injections of Mel (500 μg/day), restricted to the initiation phase of NMU mammary tumorigenesis, were ineffective in altering tumor growth over a 20-week period. When Mel treatment was delayed for 4… CONTINUE READING
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Effects of mel

  • DE Blask, A Lemus-Witson, AB Hill
  • 1991
1 Excerpt

Inhibitory effect of melatonin on prolactin stimulated growth of MCF-7 breast cancer cells (abstract)

  • AM Lemus-Wilson, DE Blask
  • J Cell Biol
  • 1990
1 Excerpt

Pineal gland, cellular proliferation and neoplastic growth: an historical account

  • RJ Reiter
  • Brain Research Promotion,
  • 1988
1 Excerpt

Rodent models to examine in vivo hormonal regulation of mammary gland tumorigenesis

  • CW Welsch
  • 1987

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