Pineal melatonin: cell biology of its synthesis and of its physiological interactions.

  title={Pineal melatonin: cell biology of its synthesis and of its physiological interactions.},
  author={Russel Joseph Reiter},
  journal={Endocrine reviews},
  volume={12 2},
  • R. Reiter
  • Published 1 May 1991
  • Biology
  • Endocrine reviews
I. Introduction UNTIL 35 yr ago, most scientists did not take research on the pineal gland seriously. The decade beginning in 1956, however, provided several discoveries that laid the foundation for what has become a very active area of investigation. These important early observations included the findings that, 1), the physiological activity of the pineal is influenced by the photoperiodic environment (1–5); 2), the gland contains a substance, N-acetyl-5-methoxytryptamine or melatonin, which… 
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