Pineal Gland Transplants into the Cerebral Hemisphere of Newborn Rats: A Study of the Blood Brain Barrier and Innervation

Abstract

Pineal glands from neonatal (0-1 day) Long-Evans black-hooded rats were transplanted into the cerebral hemispheres of litter mates for periods of 1 to 5.5 months. Grafts exhibited differentiated pinealocytes that were intensely immunoreactive for serotonin. Transplant vasculature was permeable to endogenous IgG, comprised fenestrated endothelia with wide… (More)

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