Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low.

Abstract

OBJECTIVE Positron emission tomography (PET) was used to examine whether the dose of pindolol used to augment antidepressant medication achieves a significant occupancy of the serotonin type 1A (5-HT(1A)) autoreceptor in depressed patients receiving medication. METHOD The authors examined eight depressed patients on one of two regimes of pindolol (2.5 mg… (More)

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@article{Rabiner2001PindololAO, title={Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low.}, author={Eugenii Alfredovich Rabiner and Zubin Bhagwagar and R. N. Gunn and Philip Sargent and C. J. Bench and P. J. Cowen and Paul M. Grasby}, journal={The American journal of psychiatry}, year={2001}, volume={158 12}, pages={2080-2} }