Pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine(1A/1B) antagonist, enhances the analgesic effect of tramadol.

@article{RojasCorrales2000PindololAB,
  title={Pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine(1A/1B) antagonist, enhances the analgesic effect of tramadol.},
  author={Mar{\'i}a Olga Rojas-Corrales and Antonio Ortega-{\'A}lvaro and Juan Gibert-Rahola and Ar{\'a}nzazu Roca-Vinardell and Juan Antonio Mic{\'o}},
  journal={Pain},
  year={2000},
  volume={88 2},
  pages={119-24}
}
The ability of pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine(1A/1B) antagonist, to enhance the clinical antidepressant response to selective serotonin re-uptake inhibitors is generally attributed to a blocking of the feedback that inhibits the serotoninergic neuronal activity mediated by somatodendritic 5-hydroxytryptamine (5-HT)(1A) autoreceptors. The current study examined the ability of pindolol to enhance the analgesic effect of tramadol, an atypical centrally-acting analgesic… CONTINUE READING
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