Pinacidil inhibits the ryanodine-sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein.

Abstract

Pinacidil, a potassium-channel opener, inhibited the ryanodine-sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP-sensitive K-channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist.

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@article{Xiong1991PinacidilIT, title={Pinacidil inhibits the ryanodine-sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein.}, author={Zhi Li Xiong and Shunichi Kajioka and Tsutomu Sakai and Ken Kitamura and Hirosi Kuriyama}, journal={British journal of pharmacology}, year={1991}, volume={102 4}, pages={788-90} }