PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.

@article{Yuan2009PinX1IA,
  title={PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.},
  author={Kai Yuan and Na Li and Kai Jiang and Tongge Zhu and Yuda Huo and Chong Wang and Jing Lu and Andrew Shaw and Kelwyn Thomas and Jiancun Zhang and David Mann and Jian Liao and Changjiang Jin and Xuebiao Yao},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 34},
  pages={23072-82}
}
Mitosis is an orchestration of dynamic interactions between spindle microtubules and chromosomes, which is mediated by protein structures that include the kinetochores, and other protein complexes present on chromosomes. PinX1 is a potent telomerase inhibitor in interphase; however, its function in mitosis is not well documented. Here we show that PinX1 is essential for faithful chromosome segregation. Deconvolution microscopic analyses show that PinX1 localizes to nucleoli and telomeres in… CONTINUE READING

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