Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.


Developing neurons deprived of trophic support undergo apoptosis mediated by activation of c-Jun N-terminal kinases (JNK) and c-Jun, induction of the Bcl-2 homology 3-only protein Bim(EL), Bax-dependent loss of mitochondrial cytochrome c, and caspase activation. However, the mechanisms that regulate each of these events are only partially understood. Here… (More)
DOI: 10.1111/j.1471-4159.2008.05427.x


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