Pin1 acts catalytically to promote a conformational change in Cdc25.

@article{Stukenberg2001Pin1AC,
  title={Pin1 acts catalytically to promote a conformational change in Cdc25.},
  author={P. Todd Stukenberg and Marc W Kirschner},
  journal={Molecular cell},
  year={2001},
  volume={7 5},
  pages={
          1071-83
        }
}
Pin1 is an essential protein that can peptidyl-prolyl-isomerize small phosphopeptides. It has been suggested that Pin1 regulates entry into mitosis by catalyzing the cis/trans-isomerization of prolines on critical protein substrates in response to phosphorylation. We show that Pin1 catalytically generates a conformational change on the mitotic phosphatase Cdc25, as assayed by limited protease digestion, differential reactivity to a phosphoserine-proline-directed monoclonal antibody (MPM-2), and… CONTINUE READING
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