Pimozide treatment of Sydenham's chorea

@article{Shannon1990PimozideTO,
  title={Pimozide treatment of Sydenham's chorea},
  author={Kathleen M. Shannon and Gerald M. Fenichel},
  journal={Neurology},
  year={1990},
  volume={40},
  pages={186 - 186}
}
Pimozide, a diphenylbutylpiperidine, is similar to haloperidol, has a strong blocking effect on the postsynaptic dopamine receptor, and is approved for use in the United States for the management of Gilles de la Tourette’s syndrome. The usual effective dose in the treatment of Tourette’s syndrome is 3 to 8 mg/d. Transitory sedation is the only common adverse reaction and it usually occurs when therapy is initiated with large doses. Less common dose-related adverse reactions are parkinsonism… Expand

Topics from this paper

Sydenham's chorea: a practical overview of the current literature.
TLDR
Antibiotic treatment and a 2-week or 3-week schedule of antibiotic prophylaxis are recommended and dopamine receptor blocking agents or corticosteroids can be used in more severely affected patients. Expand
Successful treatment of rheumatic chorea with carbamazepine.
TLDR
It is suggested that carbamazepine may serve as a first-line treatment for rheumatic chorea, as shown in patients who received a second trial of the drug with a good response. Expand
Treatment of Sydenham’s Chorea: A Review of the Current Evidence
TLDR
It is found that chorea often improves with symptomatic therapy and immunotherapy tends to be reserved for those who fail to respond, and Steroids are beneficial; however, data using IVIG and plasmapheresis are very limited. Expand
An update on the treatment of Sydenham’s chorea: the evidence for established and evolving interventions
TLDR
Small studies have demonstrated trends to support the use of immunoglobulins and steroids as therapeutic interventions for children affected by Sydenham’s chorea. Expand
Sydenham's chorea: not gone and not forgotten.
TLDR
Because the pathogenesis of Sydenham's chorea includes the production of anti-basal ganglia antibodies, therapies that modulate immune function or that restore neurotransmitter balance within the basal ganglia may be effective forSydenham’s chorea. Expand
The antipsychotics. A pediatric perspective.
TLDR
Results from most preliminary studies with atypical antipsychotics indicate that these are promising agents for pediatric patients, but further research is needed to define just how these medications may be most judiciously used. Expand
Successful treatment of Sydenham chorea with olanzapine
TLDR
Evaluated the efficacy of olanzapine in six children with Sydenham chorea and found encouraging results with no adverse effects. Expand
Sydenham's Chorea: A Clinical Follow-Up of 65 Patients
TLDR
Sydenham's chorea is still an important health problem in Turkey with respect to its morbidity and drug therapy was not needed in 18.5% of the patients. Expand
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders
TLDR
This new animal model translates directly to human disease and led to discover autoantibodies targeted against dopamine D1 and D2 receptors in the rat model as well as in SC and other streptococcal-related neuropsychiatric disorders. Expand
Sydenham’s Chorea, PANDAS, and Other Post-streptococcal Neurological Disorders
A 12-year-old boy developed hyperthyroidism secondary to Grave’s disease, which was successfully treated with I-131 treatment. Several months later, pharyngeal infection with group A β-hemolyticExpand
...
1
2
3
...

References

SHOWING 1-10 OF 14 REFERENCES
Pimozide: Use in Tourette's Syndrome
TLDR
Pimozide should be reserved for teatment of patients with TS who have not responded to haloperidol or who cannot tolerate haloperIDol's adverse effects, and may cause severe side effects with prolonged use and/or at higher doses. Expand
The clinical and surgical feature in 40 patients with primary cerebellar ectopia (adult Chiari malformation).
TLDR
It should be emphasised that primary cerebellar ectopia is not uncommon and is an important syndrome in its own right and in these patients the diagnosis can be difficult without supine myelography. Expand
Experience with Arnold-Chiari malformation, 1960 to 1970.
TLDR
A retrospective study of 60 adult patients with Arnold-Chiari malformation revealed that certain presenting clinical syndromes seemed to have definite prognostic significance and patients who presented with paroxysmal intracranial hypertension or cerebellar dysfunction had the best prognosis. Expand
Central nervous system anomalies associated with meningomyelocele, hydrocephalus, and the Arnold-Chiari malformation: reappraisal of theories regarding the pathogenesis of posterior neural tube closure defects.
TLDR
The frequency and pattern of brain malformations associated with neural tube defects of some children with meningomyelocele suggest that such mal Formations may seriously affect intellectual outcome. Expand
Position of Cerebellar Tonsils in the Normal Population and in Patients with Chiari Malformation: A Quantitative Approach with MR Imaging
TLDR
Magnetic resonance imaging was used to define quantitatively the position of the cerebellar tonsils in the normal population and in patients with Chiari malformations, and extension of the tonsils below the foramen magnum is considered normal up to 3 mm, borderline between 3 and 5 mm, and clearly pathologic when it exceeds 5 mm. Expand
Clinical features and longterm treatment with pimozide in 65 patients with Gilles de la Tourette’s syndrome
  • J Neurol Neurosurg Psychiatry
  • 1986
Successful treatment of refractory Sydenham’s 1 8 6 NEUROLOGY 40 January 1990 chorea with pimozide
  • J Neurol Neurosurg Psychiatry 1985;48390. enham chorea: an update
  • 1980
enham chorea: an update
  • J Neurol Neurosurg Psychiatry
  • 1980
The Arnold-Chiari malformation.
...
1
2
...