Pimozide combined with behavior therapy in the short‐term treatment of anorexia nervosa

  title={Pimozide combined with behavior therapy in the short‐term treatment of anorexia nervosa},
  author={Walter Vandereycken and Roland A. Pierloot},
  journal={Acta Psychiatrica Scandinavica},
Eighteen female inpatients were included in a double‐blind placebo‐controlled cross‐over study aimed at testing the hypothesis that dopamine blockade may enhance the effectiveness of behavior therapy in the short‐term weight restoration of anorexia nervosa patients. The patients were given a uniform contingency management program and, after a baseline period, they alternatingly (3‐ week periods) received pirnozide (4 or 6 mg) or a placebo. During the first two periods pimozide almost… 
Neuroleptics in the short-term treatment of anorexia nervosa. A double-blind placebo-controlled study with sulpiride.
  • W. Vandereycken
  • Psychology, Medicine
    The British journal of psychiatry : the journal of mental science
  • 1984
There is a remarkable lack of controlled investigations about the usefulness of psychotropic drugs in anorexia nervosa despite the popular use of neuroleptics in these patients. Inspired by a
The role of drug therapies in the treatment of anorexia and bulimia nervosa: a review of the literature
Conclusion Even if there have been useful researches on the efficacy of pharmacotherapy in the treatment of BN, there are still many unsolved issues regarding the optimal management of other EDs.
Pharmacotherapy of Eating Disorders: A Critical Review
Both uncontrolled and controlled trials have found antidepressant drugs effective in bulimia, and they represent the pharmacotherapy of first choice.
Pharmacological Treatment of Anorexia Nervosa: A Retrospective Study in Preadolescents and Adolescents
Combined with a multidisciplinary approach that includes nutritional rehabilitation and psychotherapy, adjunctive pharmacotherapy may be useful in addressing both eating disorder psychopathology and comorbid psychiatric disorders.
Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: a pilot study.
Given the overall trend toward improvement that was observed, quetiapine appears to be a promising candidate for the treatment of anorexia nervosa, and further large-scale placebo-controlled clinical trials will be necessary to fully evaluate the benefits of quet iapine treatment for this disorder.
Anorexia nervosa. Treatment efficacy of cyproheptadine and amitriptyline.
There was a differential drug effect present in the bulimic subgroups of the anorectic patients: cyproheptadine significantly increased treatment efficiency for the nonbulimic patients and significantly impaired treatment efficiency when compared with the amitriptyline- and placebo-treated groups.
Behavioural Psychotherapy of Eating Disorders
This paper reviews behavioural and cognitive-behavioural treatments of anorexia nervosa, bulimia nervosa, and obesity. For anorexia and bulimia a review is attempted of controlled trials with a cell
Advances in the Treatment of Anorexia Nervosa and Bulimia Nervosa
It is hoped that over time, with reduced cultural pressures to diet and with more emphasis on early detection of those individuals at risk of developing eating disorders, the occurrence and complications of these disorders will be reduced.
Reports of Olanzapine Treatment of Anorexia Nervosa
Two females with severe anorexia nervosa were treated with olanzapine in open trials. Olanzapine was tried because it has caused weight gain in other patient groups. Both anorexic patients had a
Pharmacologic Approaches in the Treatment of Eating Disorders
This review focuses primarily on summarizing results of published controlled trials of pharmacotherapy in patients with bulimia nervosa, and outlines the more limited literature on controlled pharmacotherapy trials for anorexia nervosa and for the provisionally identified syndrome of binge eating disorder.


Short-Term Weight Restoration in Anorexia Nervosa Through Operant Conditioning
Abstract Operant conditioning was applied to a total of 32 female anorexia nervosa patients in order to restore their normal weight. A comparative study was carried out on two groups of 16 patients
An inpatient treatment program for anorexia nervosa patients
An inpatient treatment program for anorexia nervosa, in which 145 female patients have been admitted, consists of a first “symptom directed” phase aiming at weight restoration and normalization of eating, based mostly on behavior therapy principles.
Perils of behavior modification in treatment of anorexia nervosa.
In this series of patients, this method led to deterioration, and in spite of bringing about a transient weight increase, behavior modification must be looked upon as potentially damaging in anorexia nervosa.
La therapie comportementale de l'anorexie nerveuse
Abstract Two different treatments of anorexia nervosa are compared in this study, both of which were performed successively by the same team, in the same care unit of a general hospital. The first
Behaviour therapy in anorexia nervosa.
There was no overall significant difference in weight gain in the two groups except in a subset of patients: those with no prior out-patient treatments.
Elements of resistance to a combined medical and psychotherapeutic program in anorexia nervosa. An overview.
The outcome in a group of 32 female patients who could be considered as homogeneous in a number of aspects is studied, finding that a better prognostic outcome is offered by the following personality characteristics, determined by psychological testing: lower neuroticism and higher self-defensiveness on the ABV; a lower general profile and especially a lower score on the schizophrenia scale of the MMPI.
Attitudinal dimensions in anorexia nervosa.
These scales were administered to 105 anorexia nervosa patients periodically over time in a study designed to test the effects of cyproheptadine and behavior modification on weight gain and on a variety of other characteristics in anorexic patients.
Anorektiskt beteende: Nosologiska synpunkter och presentation av en skattningsskala
Det anorektiska beteendet ar karakteristiskt for patienter med s k akta anorexia nervosa. Det kan aven vara av mera ospecifik natur med eller utan senare overgang i en avancerad anorexia
The use of non-parametric methods in the statistical analysis of a complex split plot experiment.
  • G. Koch
  • Mathematics, Medicine
  • 1970
It is shown that non-parametric methods provide realistic alternatives in analyzing data arising from a complex experimental design and not necessarily satisfying the traditional assumptions of analysis of variance.
An inpatient treatment program
  • Verhaest
  • 1982