Pimozide: Use in Tourette's Syndrome

  title={Pimozide: Use in Tourette's Syndrome},
  author={Donald C. Mcleod and Carol L. Colvin and Roberta M. Tankanow},
  booktitle={Drug intelligence \& clinical pharmacy},
The orphan drug pimozide was recently approved for marketing in the U.S. for the treatment of Tourette's syndrome (TS). TS is characterized by recurrent, involuntary motor movements and vocal tics, and is believed to be due to neurochemical dysfunction. Pimozide's receptor selectivity differs from that of haloperidol, the standard agent used for TS. Clinical trials with pimozide demonstrate a positive response for many patients, although superiority over haloperidol has not been demonstrated in… 

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