Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.

@article{Chou2008PimelicD1,
  title={Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.},
  author={C James Chou and David M. Herman and Joel M. Gottesfeld},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 51},
  pages={35402-9}
}
Histone deacetylase (HDAC) inhibitors, including various benzamides and hydroxamates, are currently in clinical development for a broad range of human diseases, including cancer and neurodegenerative diseases. We recently reported the identification of a family of benzamide-type HDAC inhibitors that are relatively non-toxic compared with the hydroxamates. Members of this class of compounds have shown efficacy in cell-based and mouse models for the neurodegenerative diseases Friedreich ataxia… CONTINUE READING

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