Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis.

@article{Hoetzenecker2005PimecrolimusLT,
  title={Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis.},
  author={Wolfram Hoetzenecker and Rupert Ecker and Tamara Kopp and Anton Stuetz and Georg Stingl and Adelheid Elbe-B{\"u}rger},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={115 6},
  pages={1276-83}
}
BACKGROUND Apart from the long-used corticosteroids, topical calcineurin inhibitors (tacrolimus, pimecrolimus) represent novel therapeutic options for the treatment of atopic dermatitis. OBJECTIVE This study was designed to investigate the pathophysiological target cells and mode of action of pimecrolimus in atopic skin. METHODS Twenty-two patients were randomly assigned to treatment with pimecrolimus cream 1%, matching vehicle cream, or beta-methasone-17-valerate (BMV) cream 0.1% in a… CONTINUE READING
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