Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders

@article{Abbas2008PimavanserinTA,
  title={Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders},
  author={Atheir I. Abbas and Bryan L. Roth},
  journal={Expert Opinion on Pharmacotherapy},
  year={2008},
  volume={9},
  pages={3251 - 3259}
}
  • A. Abbas, B. Roth
  • Published 28 November 2008
  • Medicine, Psychology
  • Expert Opinion on Pharmacotherapy
Background: Pimavanserin tartrate is the first 5-HT2A inverse agonist to enter clinical trials as a treatment for L-dopa-induced psychosis in Parkinson's disease and for augmentation of low-dose risperidone treatment in schizophrenia. Pimavanserin is also being evaluated as a possible anti-insomnia drug. Objective: To discuss the potential of pimavanserin to fill multiple therapeutic needs. Methods: The problems with currently approved antipsychotics and sleep agents are explored to highlight… 
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