Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice

@article{Feldman1997Pim1CW,
  title={Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice},
  author={Brian J. Feldman and Tony R. Reid and Michael L. Cleary},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={2735-2742}
}
Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes that cooperate with the E2A-PBX1 transgene in lymphomagenesis. Neonatal retroviral infection substantially reduced length of survival due to accelerated development of lymphomas (81 versus 130 days). The Pim1 gene was targeted by retroviral insertions in 48% of accelerated lymphomas… CONTINUE READING

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