Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.

@article{Li2006Pim3AP,
  title={Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.},
  author={Yingyi Li and Boryana Konstantinova Popivanova and Yuichiro Nagai and Hiroshi Ishikura and Chifumi Fujii and Naofumi Mukaida},
  journal={Cancer research},
  year={2006},
  volume={66 13},
  pages={6741-7}
}
Pancreatic cancer still remains a serious health problem with <5% 5-year survival rate for all stages. To develop an effective treatment, it is necessary to identify a target molecule that is crucially involved in pancreatic tumor growth. We previously observed that Pim-3, a member of the proto-oncogene Pim family that expresses serine/threonine kinase… CONTINUE READING