Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.

@article{Peltola2004Pim1KI,
  title={Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.},
  author={Katriina J Peltola and Kirsi Paukku and Teija L T Aho and Marja Ruuska and Olli Silvennoinen and P. Koskinen},
  journal={Blood},
  year={2004},
  volume={103 10},
  pages={3744-50}
}
Signal transducer and activator of transcription 5 (STAT5) plays a critical role in cytokine-induced survival of hematopoietic cells. One of the STAT5 target genes is pim-1, which encodes an oncogenic serine/threonine kinase. Here we demonstrate that Pim-1 inhibits STAT5-dependent transcription in cells responsive to interleukin-3, prolactin, or erythropoietin. Ectopic expression of Pim-1 in cytokine-dependent FDCP1 myeloid cells results in reduced tyrosine phosphorylation and DNA binding of… CONTINUE READING

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