Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells.

@article{Glazova2005Pim1KE,
  title={Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells.},
  author={Margarita Glazova and Teija L T Aho and Alois Palmetshofer and Alexander Murashov and Mika Scheinin and P. Koskinen},
  journal={Brain research. Molecular brain research},
  year={2005},
  volume={138 2},
  pages={116-23}
}
The activity of NFATc family transcription factors is tightly regulated in T cells via signaling pathways initiated by stimulation of the T cell receptor or its downstream effectors such as the Pim-1 serine/threonine kinase. Here, we demonstrate that NFATc-dependent transcription is inducible also in NGF-differentiated rat PC12 pheochromocytoma cells treated with phorbol esthers, calcium ionophores and/or forskolin and that the Pim-1 kinase can further potentiate the effects of these agents… CONTINUE READING