Pilus-mediated adhesion of Neisseria meningitidis: the essential role of cell contact-dependent transcriptional upregulation of the PilC1 protein.

@article{Taha1998PilusmediatedAO,
  title={Pilus-mediated adhesion of Neisseria meningitidis: the essential role of cell contact-dependent transcriptional upregulation of the PilC1 protein.},
  author={Muhamed-Kkeir Taha and Philippe Morand and Yannik Pereira and Emmanuel Eug{\`e}ne and Dario Giorgini and Mireille Larribe and Xavier Nassif},
  journal={Molecular microbiology},
  year={1998},
  volume={28 6},
  pages={1153-63}
}
Pilus-mediated adherence makes an essential contribution to the pathogenesis of Neisseria meningitidis by allowing the initial localized adherence. Pili are assembled from a protein subunit called pilin. Two proteins, PilC1 and PilC2, are also key elements in the formation of pili as the production of at least one PilC protein is required for pilus assembly. In addition, PilC1 but not PilC2 modulates adhesiveness, most probably by being the adhesin. Recently, both genes have been demonstrated… CONTINUE READING
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