Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells.

@article{Kawabe2001PiltAN,
  title={Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells.},
  author={Hiroshi Kawabe and Hiroshi Nakanishi and Minoru Asada and Akiko Fukuhara and Koji Morimoto and Masakazu Takeuchi and Yoshimi Takai},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 51},
  pages={48350-5}
}
Tight junctions (TJs) serve as a barrier that prevents solutes and water from passing through the paracellular pathway, and as a fence between the apical and basolateral plasma membranes in epithelial cells. TJs consist of transmembrane proteins (claudin, occludin, and JAM) and many peripheral membrane proteins, including actin filament (F-actin)-binding scaffold proteins (ZO-1, -2, and -3), non-F-actin-binding scaffold proteins (MAGI-1), and cell polarity molecules (ASIP/PAR-3 and PAR-6). We… CONTINUE READING