Pilsicainide for Atrial Fibrillation

  title={Pilsicainide for Atrial Fibrillation},
  author={Dr Koichiro Kumagai and Hideko Nakashima and Hideaki Tojo and Tomoo Yasuda and Hiroo Noguchi and Naomichi Matsumoto and Masahiro Ogawa and Keijiro Saku},
Pilsicainide is a class IC antiarrhythmic drug, which has a pure sodium channel blocking action with slow recovery pharmacokinetics. In experimental studies, pilsicainide has a depressant effect on intra-atrial conduction and a prolonging effect on the atrial effective refractory period (ERP). In patients with paroxysmal atrial fibrillation (AF), pilsicainide significantly prolonged the ERP of the distal pulmonary vein (PV), PV-left atrium (LA) junction and LA, and the conduction time from the… CONTINUE READING


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