Pilot study on basophil activation induced by contrast medium

  title={Pilot study on basophil activation induced by contrast medium},
  author={Ingrid B{\"o}hm and Ulrich Speck and Hans Heinz Schild},
  journal={Fundamental \& Clinical Pharmacology},
The purpose was to analyze the influence of both mono‐/dimeric X‐ray contrast media (CM) and immunological co‐factors on basophil degranulation. The study has been conducted in 31 adult patients who received nonionic CM injection for enhanced routine computed tomography examination. Plasma histamine, and basophil degranulation by using CD63 expression and flow‐cytometry in blood samples of patients receiving iotrolan or iopromide injections were analyzed in vivo and in vitro (with different… 

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