Pilot study on basophil activation induced by contrast medium

@article{Bhm2011PilotSO,
  title={Pilot study on basophil activation induced by contrast medium},
  author={Ingrid B{\"o}hm and Ulrich Speck and Hans Heinz Schild},
  journal={Fundamental \& Clinical Pharmacology},
  year={2011},
  volume={25}
}
The purpose was to analyze the influence of both mono‐/dimeric X‐ray contrast media (CM) and immunological co‐factors on basophil degranulation. The study has been conducted in 31 adult patients who received nonionic CM injection for enhanced routine computed tomography examination. Plasma histamine, and basophil degranulation by using CD63 expression and flow‐cytometry in blood samples of patients receiving iotrolan or iopromide injections were analyzed in vivo and in vitro (with different… 

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References

SHOWING 1-10 OF 42 REFERENCES

Detection of allergen‐induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method

The preliminary results suggest that this tricolour flow cytometric method is a reliable and valuable method for the diagnosis of allergies complementing specific allergen IgE and skin test results.

The basophil activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perspectives

The basophil activation test has become a standardized tool for in vitro diagnosis of immediate allergy and is suitable for pharmacological studies on non-purified human basophils, andMulticenter studies are now required for its clinical assessment in large patient populations and to define the cut-off values for clinical decision-making.

Differential response of human basophil activation markers: a multi-parameter flow cytometry approach

Use of polychromatic flow cytometry allowed efficient basophil electronic purification and identification of different behaviors of the major activation markers, including CD203c as a more sensitive marker than CD63, in response to fMLP but not inresponse to anti-IgE and to calcium ionophore.

Effect of radiographic contrast media on histamine release from human mast cells and basophils.

Diatrizoate induced Histamine release from all three cell types with optimal levels of histamine release after a 2-4 h incubation although significant levels occurred within 15 min, suggesting that hyperosmolality per se can induce histamines release from basophils and mast cells.

Effect of interleukin 2 on basophil histamine release

The results indicate that IL‐2 enhances basophil histamine release and some part of the effect of IL-2 on basophils is derived from other factors contained in conventional IL‐1 and RIL‐2.

Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy.

Complement Activation and Histamine Release following Administration of Roentgen Contrast Media

The results indicate that iodixanol does not activate the complement cascade when added to human serum, and that it is unlikely that anaphylactoid reactions observed in man after CM administration are caused by CM-induced anAPHylatoxins.

In vitro andin vivo studies of radiographic contrast media-induced histamine release in pigs

The susceptibility of cardiac mast cells to RCM-induced histamine release suggests that patients undergoing e.g. coronary angiography may be especially at risk for an adverse reaction.