Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer.

@article{Machtay2004PilotSO,
  title={Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer.},
  author={Mitchell Machtay and David I. Rosenthal and Ara A. Chalian and Robert Lustig and Diane Hershock and Linda Kenney Miller and G Weinstein and Randal S. Weber},
  journal={International journal of radiation oncology, biology, physics},
  year={2004},
  volume={59 1},
  pages={72-7}
}
PURPOSE Salvage surgery alone after radiotherapy (RT) failure for locally advanced head-and-neck cancer is frequently unsuccessful because of subsequent recurrence. We designed a prospective protocol to determine the feasibility, toxicity, and preliminary efficacy of a regimen of postoperative reirradiation, chemotherapy and the radioprotector amifostine after salvage head-and-neck surgery. METHODS AND MATERIALS Eligible patients had biopsy-proven locally advanced, but resectable, recurrence… CONTINUE READING

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