Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.

@article{Sandlund2014PilotSO,
  title={Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies.},
  author={John T. Sandlund and Melissa M. Hudson and Wendy Kennedy and Mihaela M Onciu and Michael B. Kastan},
  journal={Pediatric blood & cancer},
  year={2014},
  volume={61 2},
  pages={360-2}
}
Children with ataxia-telangiectasia (A-T) and cancer have a poorer prognosis due in part to increased treatment-related toxicity. We piloted a curative intent approach in five children with A-T who presented with advanced stage (III, n = 2; IV, n = 3) B-NHL (diffuse large B-cell lymphoma, n = 4; Burkitt leukemia, n = 1) using a modified LMB-based protocol. Two achieved sustained CCR (one, CCR at 6 years; one, pulmonary death after 3 years in CCR). Two died from toxicity during induction and 1… CONTINUE READING
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