Pilot study of flesinoxan, a 5‐HT1A agonist, in major depression: Effects on sleep REM latency and body temperature

@article{Ansseau1993PilotSO,
  title={Pilot study of flesinoxan, a 5‐HT1A agonist, in major depression: Effects on sleep REM latency and body temperature},
  author={Marc Ansseau and William Pitchot and Antonio Gonzalez Moreno and Jacques Wauthy and Patrick Papart},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={1993},
  volume={8}
}
Flesinoxan is a highly potent and selective 5‐HT1A full agonist, active in several models of depression. In this pilot open study, flesinoxan (4 mg/d) was administered orally for 4 weeks in 16 major depressive, mostly treatment‐resistant inpatients exhibiting a score of at least 19 on the Hamilton depression sale. Weekly ratings included Hamilton depression scale, Montgomery and Asberg depression scale (MADRS), and Clinical Global Impressions (CGI). Results showed considerable improvement in… 

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TLDR
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TLDR
Investigation of immunoreactivity for the immediate early gene protein product Fos (Fos‐ir) in rat brains 1 h after flesinoxan treatment suggests the involvement of corticotropin‐releasing hormone (CRH) or vasopressin in the hypothalamus, which suggests its activating effects on the HPA axis via CRH neurons in the PVN.

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