Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine.

@article{Theodorescu2005PilotSO,
  title={Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine.},
  author={Dan Theodorescu and Danilo Fliser and Stefan Wittke and Harald Mischak and Ronald Krebs and Michael R. Walden and Mark Ross and Elke Eltze and Olaf Bettendorf and Christian Wulfing and Axel Semjonow},
  journal={Electrophoresis},
  year={2005},
  volume={26 14},
  pages={2797-808}
}
We describe the use of capillary electrophoresis (CE) coupled with mass spectrometry (MS) to identify single polypeptides and patterns of polypeptides specific for prostate cancer (CaP) in human urine. Using improved sample preparation methods that enable enhanced comparability between different samples, we examined samples from 47 patients who underwent prostate biopsy. Of this group, 21 patients had benign pathology and 26 with CaP, and these were used to define potential biomarkers, which… CONTINUE READING

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