Pilot study of Mylotarg, idarubicin and cytarabine combination regimen in patients with primary resistant or relapsed acute myeloid leukemia

  title={Pilot study of Mylotarg, idarubicin and cytarabine combination regimen in patients with primary resistant or relapsed acute myeloid leukemia},
  author={Yesid Alvarado and Apostolia-Maria Tsimberidou and Hagop M Kantarjian and Jorge E. Cortes and Guillermo Garcia-Manero and Stefan H Faderl and Deborah A. Thomas and Elihu Estey and Francis J Giles},
  journal={Cancer Chemotherapy and Pharmacology},
Abstract Purpose. Mylotarg has moderate activity as a single agent in patients with CD33-positive refractory or relapsed acute myelogenous leukemia (AML). A combination of an anthracycline and cytarabine (ara-C) is the core of most AML induction regimens. We conducted a pilot study of Mylotarg combined with idarubicin and ara-C in patients with refractory or relapsed AML. Methods. Mylotarg was administered at 6 mg/m2 intravenously on days 1 and 15, idarubicin 12 mg/m2 daily on days 2 through 4… CONTINUE READING


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