Pilot study: Raman spectroscopy in differentiating premalignant and malignant oral lesions from normal mucosa and benign lesions in humans.

@article{Guze2015PilotSR,
  title={Pilot study: Raman spectroscopy in differentiating premalignant and malignant oral lesions from normal mucosa and benign lesions in humans.},
  author={Kevin A Guze and Hanna C. Pawluk and Michael Short and Haishan Zeng and Jochen H. Lorch and Charles M. Norris and Stephen T. Sonis},
  journal={Head & neck},
  year={2015},
  volume={37 4},
  pages={
          511-7
        }
}
BACKGROUND Current practice for differentiating tissue lesions are based on histopathological criteria. This process is subject to error. The purpose of this study was to test whether an alternative, tissue-based molecular signatures Raman spectra could be used to differentiate premalignant and malignant lesions from normal mucosa or benign lesions. METHODS Eighteen treatment naive subjects with histologically diagnosed oral disease were studied by comparing the Raman spectra of lesions with… CONTINUE READING
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