Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture.

@article{Marcantonio2011PilotRT,
  title={Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture.},
  author={Edward R. Marcantonio and Kerry Palihnich and Paul Appleton and Roger B. Davis},
  journal={Journal of the American Geriatrics Society},
  year={2011},
  volume={59 Suppl 2},
  pages={S282-8}
}
OBJECTIVES To determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair. DESIGN Pilot double-masked randomized placebo-controlled trial. SETTING Large academic medical center. PARTICIPANTS Sixteen individuals aged 70 and older with hip fracture. INTERVENTION Donepezil 5 mg or placebo was randomly allocated and initiated within 24 hours of surgery, preoperatively or postoperatively. Daily treatment was… CONTINUE READING
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